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تلقى علومه في برلين وفرايبوراغ وستراسبورغ وهايدلبرغ عمل استاذا في كيل ثم في المعهد القيصري لعلم الأحياء فرأس قسم الفيزيولوجيا . اشتهر بدراسة للأستقلاب السكري في العضلات حيث أظهر أن الغليكوجين النشا الحيواني يتحول في العضلات إلى حامض اللبن وأن جزاء من الباقي أي حامض اللبن يعود لينقلب إلى غليكوجين بوساطة الأكسجين اشترك ميرهوف مع هل بجائزة نوبل للطب سنة 1922


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